Most of your around-town driving will be done on the idle and progression circuits, and the mains don’t really come into it until you put your foot down and get the RPMs up. Start by making sure that your idle mixture screws are properly set, and that the accelerator pump is working properly. Holleys also have a high-speed enrichment device called a power valve, which can be blown by backfires through the carburetor and then cause tuning problems. There are updated backfire-proof models available and if you’re contemplating going into the carb anyway, you might want to replace this part.
The power valves are also available with different manifold vacuum threshold settings – choose one that’s appropriate for your camshaft.